Endocrine Abstracts

Diabetic lipemia, remains a well recognized but rare manifestation of uncontrolled diabetes mellitus. Although prompt diagnosis and insulin treatment have probably reduced the incidence of hyperlipemia in symptomatic diabetes, reports of this poorly understood syndrome continue to appear. 48 year old male presented with a 2 day history of severe epigastric pain, radiating to his back. Associated symptoms included nausea with vomiting. Lethargic, tired and associated headaches....

Background: Syndrome of Inappropriate Anti-diuretic Hormone (SIADH) secretion is the most common cause of hyponatremia in cancer patients. About 14% of hyponatremia in medical inpatients is due to underlying tumor-related conditions. We performed an audit to evaluate prevalence of lung malignancy in patients newly diagnosed with SIADH and to assess proportion of patients having radiological evidence of lung cancer through chest x ray and/or CT chest imaging six months after es...

Background: Maturity-onset diabetes of the young (MODY) is a group of 13 monogenic forms of diabetes transmitted in an autosomal dominant pattern and is characterized by a primary defect in pancreatic β-cell function. This disease has an early onset, usually before 25 years of age. It may present with mild asymptomatic hyperglycemia with progressive development to clinical diabetes mellitus. First-line treatment relies on sulphonylureas or insulin according to MODY subtyp...

Introduction: Immobilization hypercalcemia is uncommon condition associated with limited movements following brain and spinal cord lesions. Immobilization results in stimulation of osteoclastic bone resorption hypercalciuria and hypercalcemia.Case report: 57 year female, Background of Breast Cancer (Treated with Skin sparing mastectomy and adjuvant radiotherapy) admitted following large subdural hematoma leading to craniotomy and evacuation of hematoma. ...

Introduction: Paraneoplastic endocrine syndrome such as hypercalcemia in malignancy is well-known. However, paraneoplastic insulin resistance is rarely described and its management is challenging.Case history: A 33 years old teetotal gentleman with BMI of 37.5 kg/m2 and histological diagnosis of desmoid tumour presented with osmotic symptoms, weight loss, hyperglycemia and normal ketones. He was hemodynamically stable with no clinical or bioch...

Thyroid storm is rare and life threatening manifestation of thyroid hormone excess. It has high mortality rate with delayed treatment. As early intervention is associated with improved patient outcome, prompt diagnosis based on clinical grounds is of paramount importance. We present a case of thyroid storm which was different in terms of absence of fever on presentation, presence of thrombocytopenia and deranged cholestatic LFTs which resolved after treatment of thyroid storm....

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) which is widely used for the management of type 2 diabetes as well as for the obesity treatment. Evidence suggest that the level of HbA1c reduction and weight loss with oral semaglutide were similar to those of the subcutaneous formulation1. However, oral formulation not only improves the patient’s compliance to treatment but also makes it a favourable option for those who are relu...

Background: Pituitary abscess is rare but a serious intrasellar infection. It should be considered in the differential diagnosis of the sellar masses due to its high morbidity and mortality rates. Despite recent advances in radiological investigations, it remains a challenge to make a definitive diagnosis preoperatively [1]. We present a case of pituitary abscess who presented with pan hypopituitarism and central diabetes insipidus.Case presen...